IGFBP7, one of the seven IGFBPs identified in the mammalian genome that is used to transport and regulate the bioavailability of IGF1 and IGF2, is deregulated in PTSD and dementia via Igfbp7 promoter DNA methylation in mouse and human brains [91, 98]. Here, IGFBP7 is linked to post-traumatic stress disorder.