An increased expression of HDAC2 in human AD samples (hippocampal area CA1 and entorhinal cortex) and also in the hippocampal area CA1 and in prefrontal cortex of the CK-p25 mice and the 5XFAD model has been described [141], reinforcing the idea of using HDACi to treat AD. The gene discussed is HDAC2; the disease is Alzheimer disease.