Regarding other hallmarks of AD, hyperacetylation of H3 on the promoter of BACE1 in 3xTg brains [130] leading to increased transcriptional activity of the gene, as well as on the promoter of BACE1 and PS1 in N2a cells expressing a mutated form of APP, has been described [150]. Here, PSEN1 is linked to Alzheimer disease.