Subgroup analysis revealed that SBP (odds ratio: 1.126, 95% CI 1.024–1.237, P = 0.014) and GFR (odds ratio: 0.858, 95% CI 0.739–0.996, P = 0.043) were the independent predictors of arterial stiffness in hypertensive patients without MetS, while adiponectin (odds ratio: 0.909, 95% CI 0.931–0.996, P = 0.040) was the independent predictor of arterial stiffness in hypertensive patients with MetS (Table 5). The gene discussed is ADIPOQ; the disease is metabolic syndrome.