Our study also revealed that lower adiponectin, elevated insulin and HOMA-IR values, higher CRP, fasting glucose, TG, and lower HDL-C levels and increased BW, WC, BMI, SBP, and bilateral baPWV values exhibited a statistically significant difference between patients with hypertensive MetS and those without MetS, suggesting that circulating adiponectin concentration has association with insulin resistance and other metabolic risks. The gene discussed is ADIPOQ; the disease is Insulin resistance.