HLA-DRA and cancer: Only a few genes (TAP1, TAP2, HLA-DRA, HLA-DPA1, and NLRC5) related to antigen presentation displayed a positive correlation with mutation or neoantigen load, and only NLRC5, a negative regulator of NF-kappaB and type I interferon signaling pathways (16), which we recently also identified as a target for immune evasion in cancer (17), showed an association with neoantigen load in both cervical cancer data sets (Figure 3).