In addition, H19 inhibition was found to decrease human umbilical vein endothelial cells (HUVEC) growth and capillary formation, while the H19-miR-675 axis targets calcium/calmodulin dependent protein kinase II Delta (CaMKIIδ), thus serving as a negative regulator of cardiac hypertrophy (Liu et al., 2016). Here, H19 is linked to cardiac hypertrophy.