AGT and achalasia-alacrima syndrome: Of note, the two key inhibitors of MMPs, tissue inhibitor of metalloproteinase 3 (TIMP3) and reversion-inducing-cysteine-rich protein with kazal motifs (RECK), which lead to both the activation of MMPs in the aortic wall and the development of AAAs in the mouse AngII infusion model, were validated as direct targets of miR-712.