RNCR3 expression is significantly upregulated in mouse and human aortic atherosclerotic lesions, and inhibition of RNCR3 was shown to be sufficient to accelerate the development of atherosclerosis, aggravate hypercholesterolemia and inflammatory factor releases, and decrease EC and VSMC proliferation. The gene discussed is MIR124-1HG; the disease is familial hypercholesterolemia.