In addition, Hatziapostolou et al. (2011) demonstrated an miRNA-inflammatory feedback loop, consisting of miR-124, IL-6R, signal transducer and activator of transcription 3 (STAT3), miR-24, and miR-629, in which the systemic administration of miRNAs prevented and suppressed hepatocellular carcinogenesis by the induction of tumor-specific apoptosis without toxic side effects. The gene discussed is STAT3; the disease is neoplasm.