Despite this, a recent work using a Parkinson-like disease mouse model has reported how sustained gene transfer–mediated ATF4 up-regulation in the dopaminergic neurons of the substantia nigra resulted in severe and caspase 3/7-dependent nigrostriatal degeneration, confirming that the PERK UPR branch plays an essential role in PD pathogenesis by activating dopaminergic neuronal loss (Gully et al., 2016). Here, EIF2AK3 is linked to Parkinson disease.