HSPA5 and Parkinson disease: On the other hand, it is worth mentioning how genetic ATF6 deletion potentiates the susceptibility to PD-inducing neurotoxins in PD experimental mouse models (Egawa et al., 2011; Hashida et al., 2012), while Bip/Grp78 over-expression exerted neuroprotective effects (Gorbatyuk et al., 2012).