One example is the ALS-related mutant form of vesicle-associated protein B (VAPB) that accumulates and is retained within the ER, and the cargo receptor protein YIF1A (Yip1-interacting factor homolog A), which is normally localized along the secretory pathway in the ERGIC (Kuijpers et al., 2013). This evidence concerns the gene YIF1A and amyotrophic lateral sclerosis.