To determine whether epidermal β-catenin activation could rescue the HF growth defects induced by Blimp1 loss, we crossed K14ΔNβ-cateninER transgenics with Blimp1(dKO) mice and neonates were treated with tamoxifen (Supplementary Figure S6d, S6e). Here, PRDM1 is linked to hydrops fetalis.