Activated CSPG4 can as well recruit the tyrosine-phosphorylated p130cas, an adaptor protein involved in the linkage of actin cytoskeleton to the extracellular matrix during cell migration, invasion and transformation [56, 57], contributing in this way to cytoskeletal reorganization and metastatic spread of CSPG4-positive tumor cells. The gene discussed is CSPG4; the disease is neoplasm.