Moreover, Smidth and collaborators interestingly changed the prospective of ACT therapy, demonstrating that the adoptive transfer of CARs directed against CD20 and CSPG4 molecules—co-expressed by less that 2% of melanoma cells—is effective in the eradication of tumor lesions, while the targeting of any other minor subset is less effective [89]. Here, CSPG4 is linked to neoplasm.