Disomy of NRAS/chromosome 1 (with or without polysomy in few cells) were detected in 59.4% (19/32) of BRAF/NRAS WT, 50% (15/30) of HET, but in only 28.6% (6/21) of High non-HET melanomas (P = 0.08). This evidence concerns the gene NRAS and melanoma.