The analysis of gene expression variation using genomewide expression and SNP arrays of neuroblastoma tumours demonstrated that the SNP might affect expression of CDKN1B. In particular, the presence of the risk allele T correlated with decreased CDKN1B mRNA expression in a set of 51 tumours (Fig. 2A; P = 0.06). Here, CDKN1B is linked to neuroblastoma.