ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Indeed, adiponectin deficiency known to exacerbate the development of obesity-related hypertension [107], adverse cardiac remodeling [108] in ischemia-reperfusion injury [109], and MI [110], increased the propensity to develop diastolic HF and diastolic dysfunction in a murine model of HFpEF/diastolic HF [111].