Two transcription factors control the miR-132 locus: the cAMP-response element binding protein (CREB), indicating up-regulation under elevated Ca++; and the Repressor Element 1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF), known to be modulated under aging (Lu et al. 2014) and in AD (González-Castañeda et al. 2013; Lu et al. 2014; Orta-Salazar et al. 2014). The gene discussed is REST; the disease is Alzheimer disease.