Peshakov et al. confirmed a selective cytotoxic and anti-proliferative effect of Ca2+ overload and caspase-induced apoptosis in AML cells using a combination of curcumin and carnosic acid, however the authors did not test AML cells with the FLT3/ITD mutation, so it is unknown if this strategy has greater effects on that subset of AML45. Here, FLT3 is linked to acute myeloid leukemia.