Our study indicates that apolipoproteins of high-density lipoproteins-cholesterol (HDL-C) such as Apolipoprotein CI (APOC1; P02654), Apolipoprotein C2 (APOC2; P02655), Apolipoprotein A4 (APOA4; P06727) and Paraoxonase 1(PON1; P27169) were down-regulated along with the alterations in HDL-C transport (LCAT) in vivax malaria. Here, APOA4 is linked to Plasmodium vivax malaria.