Plasma from GTKO.hCD46.hTBM PAEC (no CHC)/human blood mixtures showed reduced levels of all markers compared to plasma from WT PAEC (no CHC)/human blood (C5a, sC5b-9, PAI-1/tPA TAT, D-dimers: all p < 0.001) (Fig. 4A–E). The gene discussed is SERPINE1; the disease is cryohydrocytosis.