Two other studies provide further evidence for the association between circulating CRP and advanced and synchronous adenoma11, 12: Otake et al. found that the OR of circulating CRP associated with an adenoma size equal to or larger than 5 mm was more than 212, while Chiu et al. observed a positive association only in the presence of larger or multiple adenomas, highlighting the impact of size and number on the CRP-adenoma association. Here, CRP is linked to adenoma.