TYR and oculocutaneous albinism: Six genes involved in melanin biosynthesis pathway are known to cause forms of OCA and OA: TYR (tyrosinase), OCA2, TYRP1 (tyrosinase-like protein 1), SLC45A2 (solute carrier family 45 member 2), SLC24A5 (solute carrier family 24 member 5), and C10orf11 (chromosome 10 open reading frame 11) accounting for OCA subtypes 1–4 and 6–7 respectively, and GPR143 accounting for OA16, see Table 1.