ADIPOQ and brain inflammatory disease: In contrast ΔGLY mutant mice with chronically elevated endogenous adiponectin have been shown to be protected from hyperglycemia, adipose tissue hypoxia, protease inhibitor-induced lipodystrophy, as well as brain inflammation, renal fibrosis and pulmonary hypertension33, 51–53, and we found that they were protected from fibrosis in two distinct mouse models.