ADIPOQ and systemic sclerosis: Consistent with the analysis using synexpression subsets, a subpopulation of SSc biopsies (adiponectinlow, n = 29) showed decreased adiponectin pathway activity (defined as pathway score ≤ 95% C.I. of the mean score of the controls), whereas 41 SSc biopsies (adiponectinnormal) showed adiponectin signatures comparable to controls.