It is the main driver for invagination of clathrin-coated synaptic vesicles, which occurs through a process of GTP-mediated oligomeric assembly.23,24 The predominance of intractable epilepsies in patients with DNM1 encephalopathy reinforces the notion that in addition to disrupted synaptic vesicle fusion, disordered vesicle recycling may represent a key step in epileptogenesis. Here, DNM1 is linked to Encephalopathy.