The expression of myocardium APN was obviously lower in NR area than that in reflow zone (Figure 8), suggesting that APN level might be the fundamental reason for the aggravation of NR injury in T2DM rats, and that endothelium injury and myocardial microcirculation dysfunction might influence the biological functions of APN. The gene discussed is ANPEP; the disease is type 2 diabetes mellitus.