EDN1 and myocardial infarction: The level of serum ET-1, ICAM-1 and VCAM-1 were also increased significantly (Figure 7A-C) after the MI/R surgery compared with normal diet rats, which suggested that vascular endothelial injury and the dysfunction of myocardial microcirculation were aggravated further in T2DM rats after MI/R, which may be one of the reasons for the aggravation of NR injury.