While we show that Rictor loss decreases metastatic ability of HER2-driven breast tumors and that Rictor/mTORC2 directly controls cell migration, we have not ruled out the potential impact Rictor loss may have on survival of disseminated tumor cells and how this may affect seeding/establishment of overt metastases in our mouse models of metastasis used for this study. This evidence concerns the gene ERBB2 and breast neoplasm.