In contrast to the gene encoding the Rac inhibitor RhoGDI2, which correlated with a favorable outcome in breast cancer patients, increased expression of TIAM1 mRNA in the METABRIC breast cancer microarray dataset that correlated with worse outcome for patients with breast cancer (Additional file 1: Figure S5), consistent with its potential role in regulating tumor metastasis. This evidence concerns the gene AKT1 and breast carcinoma.