Interestingly, similar correlation was seen between high ARHGDIB expression and lengthened survival in a larger breast cancer dataset (N = 1660) that included all breast cancer molecular subtypes (Additional file 1: Figure S4), suggesting that RhoGDI2/ARHGDIB may be a key factor in breast tumor cell metastasis beyond the scope of HER2-amplified breast cancers. Here, ERBB2 is linked to breast neoplasm.