MAPK8 and ovarian cancer: Meanwhile, the inhibition of JNK activity, blocked by JNK specific inhibitor (SP600125), could decrease the invasive ability of ovarian cancer cells (SP600125 10 μM SKOV-3 group (42.43 ± 3.23) vs. control group (180.63 ± 9.67), p < 0.0001; SP600125 5 μM SKOV-3 group (70.97 ± 3.40) vs. control group (180.63 ± 9.67), p < 0.0001; SP600125 10 μM HO-8910 group (42.57 ± 3.56) vs. control group (179.83 ± 11.03), p < 0.0001;SP600125 5 μM HO-8910 group (71.17 ± 5.82) vs. control group (179.83 ± 11.03), p < 0.0001) (Fig. 4f and g).