Likewise, we note that vascular endothelial growth factor A (VEGF-A) was upregulated in CAD and downregulated in ACS and HF In contrast, we found thatthe proto-oncogene MYC may be a specific genetic markers for CAD, while the hematopoietic transcription factors SP1 and SOX6 are potential specific markers for ACS. Here, SP1 is linked to coronary artery disorder.