When segregated into groups, correlations were apparent that in P. vivax group, there was no association between S1P levels and laboratory parameters (parasitemia, Hb and Hct and platelet count) at day 0 (rs = -0.209; p = 0.275, rs = 0.068; p = 0.727, rs = 0.251; p = 0.189, rs = 0.070; p = 0.717, respectively) (Fig 3A–3D) and 7 (rs = 0.000; p = 0.000, rs = -0.290; p = 0.127, rs = 0.036; p = 0.853, rs = 0.019; p = 0.920, respectively). This evidence concerns the gene GSTM1 and parasitic infectious disease.