Previous studies have demonstrated an upregulation of PD-L1 on MDSCs under hypoxic conditions which further increases the immunosuppressive ability of these cells and reflecting HIF1α expression in the tumor microenvironment.[68] [69] Our data corroborates this showing relatively high levels of PD-L1 expression in mMDSCs which is then decreased upon exposure to SFN. The gene discussed is HIF1A; the disease is neoplasm.