While several recent studies relying on pharmacological approaches demonstrated a beneficial effect of oral salmon CT on body weight, fasting glycaemia and glucose tolerance in rats [12,13,14], our results confirm a potential physiological role of CT in glucose metabolism, as obese CTR-deficient animals displayed features of enhanced NASH, impaired glucose tolerance and hyperinsulinemia in vivo. This evidence concerns the gene CALCR and metabolic dysfunction-associated steatohepatitis.