In order to investigate whether these effects can be observed not only in the case of CTR-, but also CT-deficiency, mice lacking Calca, encoding CT as well as PCT and αCGRP and exhibiting normal body weights under standard conditions [24], were fed a HFD and analyzed for phenotypic differences following the same experimental protocol as for CTR-deficient mice. The gene discussed is CALCA; the disease is hyperinsulinemic hypoglycemia, familial, 4.