RBFOX3 and Thiamine deficiency: After 12 days of a thiamine-restricted diet, when most of homozygous KO mice had died of thiamine deficiency, the numbers of NeuN-immunoreactive neurons were remarkably decreased over a wide area of the thalamus, including the SMT (Figs 3F and 4A); in homozygous KI mice, the numbers of NeuN-immunoreactive neurons in the SMT and the dorsal area of the thalamus decreased to approximately 30% (Figs 3H and 4D).