Further studies are needed to determine the exact influence of c-aAb in apparently asymptomatic individuals, as well as the effect of duration of exposure to high c-aAb levels on health outcome; It is possible that the observed correlation between c-aAb and CRP or previously established links to diseases such as PAP are caused by long-lasting c-aAb responses, and that temporarily elevated levels of c-aAb represent endogenous regulation, which does not lead to such effects. This evidence concerns the gene CRP and pulmonary alveolar proteinosis.