Therefore, the purpose of this study was to evaluate the effect of cholecalciferol supplementation on the expression of TLR7, TLR9, IFN-γ, IL-6, VDR, CYP27b1 and CYP24a1 in B and T lymphocytes from dialysis patients with hypovitaminosis D. In vitro, we assessed the effect of 25 and 1,25 vitamin D on lymphocytes from healthy volunteers (HV) in the presence or absence of uremic serum related to inflammatory response mechanisms, intracellular VDR and vitamin D regulatory enzymes. This evidence concerns the gene VDR and rickets.