PRNP and Creutzfeldt Jacob disease: The models used were for human rPrP23–231 (129V) inhibition of iCJDVV2 (iatrogenic CJD, PRNP valine 129 homozygous) amplification in TgWV murine (transgenic for human 129V PRNP) substrate, where the approximate EC50 value was 60 nM, and mouse rPrP23–231 inhibition of mouse PrPSc (strain 139A) amplification in mouse brain homogenate where the approximate EC50 value was 120 nM.