TFEB and plasma cell myeloma: The transcription factor EB (TFEB) is a master gene for lysosomal biogenesis that drives expression of a large subset of autophagy genes leading to activation of autophagic cell death of myeloma cells owing to metabolic cell stress.38 RNF170 encodes an ER membrane ubiquitin ligase that mediates ubiquitination and degradation and plays a key role in cell signaling.39 Given previous reports on the association of these genes to myeloma biology and outcomes, we considered their collective inclusion in our unsupervised clustering further validation of their role in PI response.