We analyzed the metabolite profiles of plasma samples from 46 members of two unrelated families carrying different germline BAP1 mutations – the Wisconsin (W) and the Louisiana (L) families – that we have been following and treating for mesothelioma and other malignancies for >10 years.1 For details about individuals and samples, see Materials/Subjects and Methods section19 and Supplementary Table S1. This evidence concerns the gene BAP1 and mesothelioma.