TSC2 and posterior cortical atrophy: Upon siRNA-mediated knockdown of FGFR3-L, TSC2-L or RASGRP2-a (Supplementary Fig. 6a–c, top panels) in MDA PCa 2b cells, the expression ratios of FGFR3-S/FGFR-L, TSC2-S/TSC2-L and RASGRP2-b/RASGRP2-a increased and correlated with augmented invasive and/or proliferative capacity of the AA-derived MDA PCa 2b cells (Supplementary Fig. 6a–c, bottom panels).