Regarding the in-frame variants (PIK3CD-L, FGFR3-L and TSC2-L) detected in EA PCa, each conferred a less aggressive oncogenic phenotype compared with the corresponding in-frame variants detected in AA PCa (PIK3CD-S, FGFR3-S and TSC2-S). This evidence concerns the gene TSC2 and posterior cortical atrophy.