Marcucci et al. developed a transferrin-conjugated nanoparticle delivery system conjugating transferrin (Tf) to PEGylated lipopolyplex nanoparticles (Tf-LPs) which incorporates protamine as a DNA condensing agent, pH-sensitive fusogenic lipids to improve cytoplasmic delivery, and Tf as the targeting ligand specific for cellular delivery (commonly overexpressed on cancer cells and also in AML) [182]. Here, TF is linked to acute myeloid leukemia.