Oral treatment with pioglitazone, a PPAR-γ agonist, diminished motor neuron loss, enhanced motor performance, delayed weight loss, and also reduced iNOS, NF-κB, and 3-nitrotyrosine levels in spinal cords, prolonging survival by 13% of G93A SOD (transgenic mouse model of ALS) when compared with an untreated control littermate counterparts, suggesting the therapeutic potential of PPAR-γ agonists in human neuroinflammatory diseases [24,25]. The gene discussed is PPARG; the disease is amyotrophic lateral sclerosis.