In rats with CDSN pretreated with ghrelin prior to the development of cerulein-induced pancreatitis (CIP), pancreatic weight reached a value of 2050 ± 150 mg and was even slightly increased in comparison to pancreatic weight observed in sensory nerves-intact rats without pretreatment with ghrelin before induction of acute pancreatitis or rats with CDSN pretreated with saline before CIP. This evidence concerns the gene GHRL and acute pancreatitis.