The mRNA expression levels of Ppara (p = 0.006), Ppard (p = 0.027), Pparg (p = 0.045), and their target genes, including liver X receptor α (Lxr) (p = 0.043), lipoprotein lipase (Lpl) (p = 0.018), cluster of differentiation 36 (Cd36) (p = 0.006), cytochrome P450 4a10 (Cyp4a10) (p = 0.010), and acyl-Coenzyme A oxidase 1 (Acox1) (p = 0.021), in liver tissues in the PSE group were significantly greater than those in the HF group. This evidence concerns the gene PPARD and photosensitive epilepsy.