CCL2 and lupus nephritis: Additionally, in nephritic lesions of MRLlpr/lpr mice, TLR7 is expressed on renal macrophages and contributes to the production of pro‐inflammatory mediators, including IL‐12, IL‐6, CCL2, and IFN‐α, which is known to contribute to the progression of lupus nephritis (Pawar et al., 2006).