For some genes, Akt‐mediated YB‐1 phosphorylation at serine residue 102 (p‐YB‐1S102) 28 is a prerequisite for its trans‐activating capacities 6, 29 and previous studies have revealed YB‐1 phosphorylation in LPS‐challenged primary MCs and in a model of acute LPS‐triggered nephritis in vivo4. This evidence concerns the gene AKT1 and nephritis.