Using chromatin immunoprecipitation followed by quantitative real time PCR (ChIP-qPCR), we found that miR-125a and miR-320c were direct targets of PRC2 in MM cell lines and primary MM patient cells and that their reactivation, as predicted, correlated with the downregulation of expression of MM-associated oncogenes IRF-4, XBP-1, BLIMP-1 and c-MYC [28]. This evidence concerns the gene PRDM1 and Miyoshi myopathy.