In mice models of DSS-induced colitis, it has been found that celastrol ameliorates acute intestinal injury and prevents the loss of intestinal epithelial homeostasis through the reduction of colonic oxidative stress, inhibition of NLRP3-inflammasome and IL-23/IL-17 pathway, reduction of inflammatory cytokines and increase in IL-10 and TNF levels, attenuation of neutrophil infiltration and upregulation of E-cadherin expression (65, 66). Here, IL10 is linked to colitis.