CCL2 and type 1 diabetes mellitus: Contrarily, an in vitro study using RINm5F rat pancreatic β-cell line showed that celastrol regulates cytokine-induced cell death and proinflammatory responses by downregulating iNOS, COX-2, and chemokine (C-C motif) ligand 2 (CCL2) chemokine through NF-kB inhibition, exerting cytoprotective effects (181), which suggests that indeed it may be a therapeutic agent against type 1 diabetes.