In present study, geldanamycin administration markedly reduced influenza viral loads in the lung on post-infection days 2, 4, or 7 compared with the control mice, consistent with previous studies showing that geldanamycin impaired influenza virus growth by reducing the half-life of PB1 and PB2 and inhibiting nuclear import of PB1 and PA to reduce viral ribonucleoprotein (RNP) assembly (Chase et al., 2008). This evidence concerns the gene RNPC3 and infection.