RNPC3 and influenza: In present study, geldanamycin administration markedly reduced influenza viral loads in the lung on post-infection days 2, 4, or 7 compared with the control mice, consistent with previous studies showing that geldanamycin impaired influenza virus growth by reducing the half-life of PB1 and PB2 and inhibiting nuclear import of PB1 and PA to reduce viral ribonucleoprotein (RNP) assembly (Chase et al., 2008).