• Immune complexes detected in glomeruli 4–5 weekspost-induction• C57BL/6 mice develop mild nephritis with antibodydeposition in mesangial cell (class II).• BALB/c and SJL mice develop proliferative lupusnephritis with IgG deposition present along thecapillary loops.• Membranous nephritis• Electron-dense deposits in the mesangium,subendothelial, and subepithelial regions• Induction of pro-inflammatory cytokines throughupregulation of TWEAK. Here, TNFSF12 is linked to nephritis.