C3 and glomerulosclerosis: • Early onset of glomerulosclerosis compared withNZB/W F1 and MRL/lpr mice• Deposition of IgG and C3 in glomerular and tubularbasement membranes• Proliferative changes in mesangial and endothelialcells• Thickening of glomerular basement membrane• Glomerulosclerosis• Tubulo-interstitial fibrosis• Tubular atrophy