• Development of renal disease more severe in BALB/cmice than in C57BL/6 mice• Focal to global proliferative lesions• Effacement of capillaries• Glomerular basement membrane thickening• Deposition of IgG, IgM, and C3 in mesangial andsubendothelial area• Immune complexes in these mice are not attributedto IgG anti-dsDNA antibodies. The gene discussed is C3; the disease is kidney disorder.