• Deposition of IgG and C3 in glomerular and tubularbasement membranes• Proliferative changes in mesangial and endothelial cells• Thickening of glomerular basement membrane• Increased glomerular and tubulo-interstitialexpression of PKC-α, PKC-βI, PKC-βII, TGF-β1,collagen, and fibronectin• Glomerulosclerosis• Mononuclear cell infiltration into interstitium• Increased cytokine and chemokine expression• Increased tubulo-interstitial activation of MAPKsignaling pathway• Tubulo-interstitial fibrosis• Tubular atrophy. This evidence concerns the gene PRKCA and glomerulosclerosis.