A number of genes already known to cause CHD were identified, such asPTPN11 (Noonan syndrome),KMT2D (MLL2 Kabuki syndrome),MYH6 (atrial septal defects, cardiomyopathy),JAG1 (Alagille syndrome),CHD7 (CHARGE syndrome),ZEB2 (Mowat Wilson syndrome), andNOTCH1 (aortic valve disease and Adams Oliver syndrome).RBFOX2 was a novel gene. This evidence concerns the gene KMT2D and atrial septal defect.