In a separate study of 87 ‘typical’ metabolic syndrome patients, 10 patients had perturbed lamin A/C distribution and nuclear shape defects: among these, two patients had a LMNA variant (p.G411D or p.G631D), and a third patient had a ZMPSTE24 mutation and accumulated farnesylated prelamin A (Dutour et al., 2011). Here, ZMPSTE24 is linked to metabolic syndrome.