More than 219 individuals with LMNA variants in the ExAC cohort have a mutation previously observed in patients with laminopathies— predominantly but not exclusively heart disease— including 158 individuals with either p.R644C or p.R644H, and 61 individuals with p.K117R, p.S326T, p.G523R, p.S573L, or p.G602S (Figure 2A). The gene discussed is LMNA; the disease is heart disorder.