Variant p.I299V is linked to FPLD2 in the laminopathy database: a puberty-onset disorder characterized by lipodystrophy, muscle hypertrophy, and insulin-resistant diabetes (Vigouroux et al., 2000; Guénantin et al., 2014), and elevated hepatic glucose production (Rizza, 2010). Here, LMNA is linked to lipodystrophy.