These findings warrant deeper genotype/phenotype analysis to assess the full range of LMNA mutations, including splicing defects, as risk factors for new disease associations (e.g., sick sinus syndrome; Zaragoza et al., 2016) and as risk factors for complex traits including psychiatric disease (e.g., novel variant p.K108E) and Type 2 Diabetes. The gene discussed is LMNA; the disease is sick sinus syndrome.