LMNA and metabolic syndrome: In particular, Decaudain et al. (2007) studied 277 patients with severe metabolic syndrome; of these, 27 individuals (10%) had a LMNA mutation: 17 patients had variants at Ig-fold residue R482 (the hotspot for FPLD2 mutations), and 10 patients had mutations in the lamin A head domain (p.R28W), coiled-coil ‘rod’ (p.L92F), Ig-fold (p.R439C, p.H506D) or unstructured regions in the neck or tail (p.L387V, p.S395L, p.R399H, p.L421P or T655fsX49).