Hence, overall the study highlights that: (1) glioblastoma cells are vulnerable to high calcium induced macropinocytotic-hydrostatic stress; (2) BM plant extract/Bacoside A enhances CaMK2A and activates CaMK2A phosphorylation (pCaMK2A) in GCs; and (3) pCaMK2A triggers high calcium release from ER causing macropinocytotic and membrane hydrostatic stress induced tumor cell death. The gene discussed is CAMK2A; the disease is glioblastoma.