NLRP3 and neoplasm: GEO profile dataset (GDS2545) of 171 prostate tissues showed no significant differences between normal vs cancer tissues for NLRP3 (p = 0.454) and AIM2 (p = 0.616), and the expression levels in normal (no pathological alterations in the prostate tissues; n = 18), normal adjacent of tumor (n = 63), tumor tissues (n = 65), and metastatic prostate cancer to various anatomical sites (n = 25) for both the genes were almost similar (Fig. 1A and B).