The significance of the SIX1/SIX6 locus in glaucoma was initially discovered by GWAS for VCDR and primary open-angle glaucoma (POAG), and subsequent studies confirmed the association of polymorphisms in this region with glaucoma onset.9, 33, 34 According to previous GON structure-function correlations27–29, a finer cpRNFLT analysis with >4 sectors would be better suited to fully evaluate the risk of QOV-threatening VFD patterns. This evidence concerns the gene SIX1 and open-angle glaucoma.