Moreover, the genotype/phenotype relationship with SPOP mutation was confirmed in an independent non-Caucasian prostate cancer cohort of Korean men (P = 4e-02, OR = 5.84 logistic regression analysis)13, indicating that this phenomenon is not limited to Caucasian male populations but rather may extend across multi-ethnic populations (Table 1 and Fig. 1d). Here, SPOP is linked to prostate carcinoma.