Fourteen DNA repair genes and 15 hormone-regulated genes contributed to the high trigger score for the 7p14.3 variant (Supplementary Data 7), of which DAZAP2, DDX18, SET, and XRCC5 were also significantly deregulated in SPOP mutant as compared to SPOP wild-type human prostate carcinoma cases (Supplementary Fig. 2). Here, SPOP is linked to prostate carcinoma.