OXR1 and neoplasm: Considering each histological subtype separately, higher OXR1 promoter methylation levels were observed in high (3 and 4) grade tumours (median: 16,714; interquartile range: 11,993–21,817) compared to low (1 and 2) grade tumours (median: 7300; interquartile range: 355–10,715) in ccRCC only (p = 0.005) (Fig. 4).