Shun et al. showed that symptoms of depression (measured by POMS depression subscale) (p = 0.0001), functional status (measured by single item ECOG-PS) (p = 0.0003), overall symptom severity (p = 0.0001), and albumin levels (p = 0.001) were all significantly predictive for changes in QOL scores during treatment. This evidence concerns the gene ALB and depressive disorder.